Frazier (groin) is not in the lineup for Saturday's spring game against the Yankees, according to Rob Biertempfel of The Athletic.
Santana made his spring debut Friday, striking out one batter in a scoreless inning against the Phillies, DK Pittsburgh Sports reports.
Cederlind allowed one run in one inning Friday, surrendering a solo homer to the Phillies' Andrew McCutchen, DK Pittsburgh Sports reports.
Hayes went 2-for-3 with an RBI triple Thursday against Atlanta.
Anderson allowed three hits and one earned run while striking out three batters in two scoreless innings against Atlanta on Thursday.
Newman went 2-for-2 with a walk Thursday against the Braves.
Cruz will start in center field Thursday for the first time in his career, DK Pittsburgh Sports reports.
Tucker has been scratched from Wednesday's Grapefruit League lineup against the Rays due to a left hand contusion.
The Pirates scratched Oliva from the lineup for Tuesday's Grapefruit League game due to lower-back tightness.
Keller allowed two earned runs on three hits in one inning against the Blue Jays on Monday, DK Pittsburgh Sports reports.
Alford (elbow) said his injury continues to improve, even though he served as the team's designated hitter Monday against Toronto, the Pittsburgh Post-Gazette reports.
Frazier hit a home run Sunday in his Grapefruit League debut with the Pirates.
Polanco went 1-for-3 with a two-run homer Sunday against the Orioles.
Kuhl pitched one inning Sunday, allowing two singles while striking out the side, DK Pittsburgh Sports reports.
Alford (elbow) is in the starting lineup for Monday's spring game against the Blue Jays.
Evans (jaw) is in the starting lineup for Monday's spring game against the Blue Jays.
Difo is in the starting lineup for Monday's spring game against the Blue Jays.
Holmes (forearm) is scheduled to pitch in relief Sunday in the Pirates' Grapefruit League opener against the Orioles, Kevin Gorman of TribLive.com reports.
Gonzalez is in the starting lineup for Sunday's spring training opener, according to the Pirates' official Twitter account.
Brubaker is expected to battle for the team's fifth rotation spot, the Pittsburgh Post-Gazette reports.
Manager Derek Shelton expects Fowler to primarily serve as a back-up corner outfielder, the Pittsburgh Post-Gazette reports.
Frazier is absent from workouts for the second straight day Friday with an unspecified minor injury, Jason Mackey of the Pittsburgh Post-Gazette reports.
Polanco clarified Thursday that he didn't fracture his wrist over the winter, contrary to previous reports, Kevin Gorman of TribLive.com reports.
Davis (elbow) was placed on the 60-day injured list Wednesday, Alex Stumpf of DKPittsburghSports.com reports.
Fowler was traded from the Athletics to the Pirates on Wednesday in exchange for cash considerations, Rob Biertempfel of The Athletic reports.